To better understand the potential health threats and underlying visual pathways of long-term light at night (LAN) exposure, we adopted a widely accepted diurnal animal model tree shrew (Tupaia ...

In eukaryotes, genomic DNA is packaged into chromatin, which is the substrate for transcription, DNA replication, repair, and recombination. Within chromatin, nucleosomes contain two copies of each of ...

Bispecific T cell engagers (TcEs) that are able to simultaneously bind to epitopes on cancer cells and T cells are a versatile, highly potent, and economical immunotherapeutic tool ().TcEs are ...

Cotyledon greening is a crucial process for seedlings to survive the dark-to-light transition during their soil emergence. While the complex strategies employed by etiolated seedlings to ensure ...

High-resistant starch (RS)/low-glutelin sbeIIb/Lgc1 lines were generated by CRISPR-Cas9-induced site-specific mutations in SBEIIb in an elite low-glutelin japonica rice cultivar ().According to this ...

The origin of evolutionary novelties is often underpinned by a complex set of changes. The genetic underpinnings comprise, for instance, gene or genome duplication, mutations, deletions, and ...

Despite these successes, polyhydride synthesis remains challenging. For instance, it took nearly a decade to experimentally realize CaH 6 (12, 13) after its theoretical prediction ().A major hurdle is ...

Pigmentation plays a vital role in the survival of organisms, supporting functions such as camouflage, communication, and mate attraction. In vertebrates, these functions are mediated by specialized ...

Developing oral biologics has long been a holy grail of protein engineering. Traditional antibodies are large and unstable in the presence of gastrointestinal proteases. Here, we present a strategy to ...

Natural ice plays salient roles in making the Earth habitable and sustainable. Previously overlooked, its role in chemical processes is now of emerging interest, particularly due to the freeze ...

Sorting cells with target metabolic functions from a mutant pool exhibiting substantial genetic diversity is often the rate-limiting step in synthetic biology. Here, we developed a label-free, ...

Arguably, among the most demanding settings for spatial control of the endolysosomal system are highly polarized cells such as neurons, which consist of complex dendritic arbors and axons that extend ...