A 40-year-old man presented to the emergency department with a 5-day history of fevers, sore throat, fatigue, subjective ...

Gene therapy with elivaldogene autotemcel (eli-cel) consisting of autologous CD34+ cells transduced with lentiviral vector containing ABCD1 complementary DNA (Lenti-D ...

New data show that the United States continues to fall short when it comes to both protecting the health of individual people and promoting societal well-being. From the Harvard T.H. Chan School ...

Dr. Danielle C. Crabtree (Medicine): A 37-year-old man was admitted to this hospital because of fever, myalgia, jaundice, and hypoxemia. The patient had been healthy until 9 days before this ...

Whether extended lymphadenectomy is associated with improved disease-free and overall survival, as compared with standard lymphadenectomy, among patients with localized muscle-invasive bladder ...

A total of 672 persons (336 per group) were assigned to receive collagenase injection or to undergo limited fasciectomy. The primary analysis included 599 persons: 314 in the collagenase group and ...

More than 30 years ago, the first transplantation with autologous hematopoietic stem cells modified with integrated murine retroviral vectors carrying potentially therapeutic genes was performed ...

U.S. states, which are better positioned than the federal government to precisely and comprehensively address the drivers of low-value health care spending, should lead the way in establishing ...

CAR T-cell manufacturing involves T-cell apheresis, CAR transduction, and expansion of transduced autologous or allogeneic T cells. To date, approved CAR T-cell products rely on lentiviral ...

Hereditary hemorrhagic telangiectasia (HHT) is characterized by extensive telangiectasias and arteriovenous malformations. The primary clinical manifestation is epistaxis that results in iron ...

Respiratory syncytial virus (RSV) is a leading cause of severe illness in infants, with no effective treatment. Results of a phase 2 trial suggested that ziresovir may have efficacy in the ...