The results of the KEYNOTE-689 trial reported by Uppaluri et al. (July 3 issue)1 are highly important. The addition of perioperative pembrolizumab has become the new standard of ...

The painkilling, antipyretic, and antiinflammatory properties of aspirin have been known for centuries. The understanding that aspirin targets cyclooxygenase-1 (COX-1) (also known as ...

Idiopathic normal-pressure hydrocephalus is a neurologic disorder characterized by impaired gait, balance, cognition, and ...

The planned implementation of Medicaid work requirements provides an opportunity to obtain longitudinal data to guide ...

Tobacco use kills more than 7 million people worldwide each year, including 1.3 million who die from the effects of exposure to secondhand smoke.1 As a major contributor to cancer, cardiovascular ...

Michael Welsh, Jesús González, and Paul Negulescu have won the 2025 Lasker–DeBakey Clinical Medical Research Award for their roles in developing treatments for cystic fibrosis.

We randomly assigned, in a 2:2:1 ratio, participants with previously untreated EGFR -mutated (exon 19 deletion or L858R substitution), locally advanced or metastatic NSCLC to receive ...

There is an urgent need for low- and middle-income countries to ensure equitable, affordable, and sustained access to tobacco-cessation medications at scale.

In 2019, seven county correctional facilities (jails) in Massachusetts initiated pilot programs to provide all Food and Drug Administration–approved medications for opioid use disorder (MOUD). This ...

Explore the current issue of The New England Journal of Medicine (Vol. 393 No. 10).

A 54-year-old woman with infiltrating ductal carcinoma of the right breast treated with locoregional radiation presented with cough, fever, and dyspnea. CT showed fibrotic and ground-glass opacitie ...

Syphilis is one of the oldest known diseases. Approximately 209,000 cases were reported in the United States in 2023 — the highest number of reported cases since 1950 — including nearly 4000 ...