Recent genetic and biochemical studies have revealed several new aspects of glucose signaling in E.coli. For example, we found that the inhibitory effect of glucose on the utilization of lactose is ...

The protein homeostasis (proteostasis) network (Balch et al, 2008), consisting of a collection of molecular chaperones, ...

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The enteric nervous system (ENS), the largest division of autonomic nervous system, is a tantalizing frontier in neuroscience. With the advent of single-cell transcriptomics, the ENS has been ...

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Temporal organization of tissue metabolism is important for maintaining nutrient and energy homeostasis in mammals. Autophagy is a conserved cellular pathway that is activated in response to nutrient ...

Brian's research focuses intersections between circadian rhythm and cancer. He utilizes cell line and mouse models of MYC-driven lung cancer to focus on how amplified MYC and metabolic stress disrupt ...

Plants have evolved a multi‐layered system of defence responses that can be activated upon recognition of invading pathogens. One layer includes transmembrane receptors that recognize evolutionarily ...

In E. coli, the Cascade complex alone is able to generate crRNA but requires Cas3 to achieve immunity against foreign DNA (Brouns et al, 2008). Hence, Cas3 appears to be a key protein of CRISPR system ...

A phy molecule consists of two domains: an N‐terminal globular domain, which anchors the bilin chromophore and is responsible for photosensory function; and a C‐terminal domain, which is thought to be ...

The activity of the cyclin‐dependent kinase inhibitor p27 is controlled by its concentration and subcellular localization. However, the mechanisms that regulate its intracellular transport are poorly ...

The Dnmt3a DNA methyltransferase is essential for mammalian development and is responsible for the generation of genomic methylation patterns, which lead to transcriptional silencing. Here, we show ...