Hereditary proximal spinal muscular atrophy (SMA) is caused by survival motor neuron (SMN) protein deficiency due to homozygous loss of SMN1 gene function. Residual SMN protein levels are produced by ...

Standardization, innovation, and multidisciplinary teamwork could be the key On 19 Dec 2024, the Journal of Neurology, Neurosurgery, and Psychiatry (JNNP), in partnership with the Department of ...

Objective/Aims Does Subjective Cognitive Decline (SCD) indicate susceptibility to Functional Cognitive Disorder (FCD) more often than it indicates neurodegeneration? Prior research has focused on ...

Parkinson’s disease seems to occur more commonly in men than women based primarily on studies of death rates and prevalence. In recent years, several population based incidence studies of Parkinson’s ...

Sextus Empiricus (about AD 200) is credited1 with being the first person to use the word “aphasia”, albeit in a philosophical sense. Carl Wernicke's studies on aphasia, published from 1874, are among ...

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective neurosurgical treatment for Parkinson’s disease. Surgical accuracy is a critical determinant to achieve an adequate DBS ...

Background In Huntington’s disease (HD) cognitive decline can occur before unequivocal motor signs become apparent. Unfortunately, the exact progression of cognitive decline is unknown. As cognitive ...

In the last 6 years, following the first pathological description of presumed amyloid-beta (Aβ) transmission in humans (in 2015) and subsequent experimental confirmation (in 2018), clinical cases of ...

Objective Sudden unexpected death in epilepsy (SUDEP) is a leading cause of epilepsy-related mortality in young adults. It has been suggested that SUDEP may kill over 20 000 people with epilepsy in ...

Objective Vagus nerve stimulation (VNS) plus rehabilitation (Rehab) has shown a potential effect on recovery with a stroke. We systematically synthesised studies examining VNS+Rehab for improving ...

RESULTS Demographic data No significant differences were found between the two groups in terms of age (hemianopic alexia median 68 years and interquartile range {10}, pure alexia median 63 years and ...

Background There is limited data on predictors of symptomatic intracranial haemorrhage (sICH) in patients who underwent mechanical thrombectomy. In this study, we aim to determine those predictors ...