Increased exon skipping, particularly affecting proteasome-related transcripts, was mediated by elevated serine/arginine-rich splicing factor 6 (SRSF6) levels in T-cell acute lymphoblastic leukemia.

2018 Meetings Abstracts: Fifth AACR-IASLC International Joint Conference: Lung Cancer Translational Science from the Bench to the Clinic January 8–11, 2018; San Diego, CA Proceedings: AACR Annual ...

Abstract. H460 is a non-small cell lung cancer (NSCLC) cell with multidrug resistance (MDR) against a variety of anti-cancer drugs such as cisplatin and transforming growth factor-beta (TGF-beta). It ...

Abstract. In this review, we highlight recent discoveries regarding mechanisms contributing to nerve-cancer cross-talk and the effects of nerve-cancer cross-talk on tumor progression and dissemination ...

Abstract. Prostate cancer is the second most frequently occurring carcinoma in males worldwide and one of the leading causes of death in men around the world. Recent studies estimate that over 1.4 ...

AACR Journals Blood Cancer Discovery Cancer Discovery Cancer Epidemiology, Biomarkers & Prevention Cancer Immunology Research Cancer Prevention Research Cancer Research Cancer Research Communications ...

Loss of the NFκB pathway inhibitor TRAF3 increased MHC-I expression, improving T cell–mediated cancer cell killing and tumor responsiveness to immune checkpoint blockade, an effect that could be ...

An antibody–drug conjugate (ADC) class that combines a novel self-immolative T moiety and the topoisomerase I inhibitor exatecan displays higher therapeutic indices to overcome intrinsic or induced ...

AbstractSummary:. Circulating tumor cells (CTC) are the source of metastases, but only an infinitesimal fraction of them eventually succeed in colonizing a distant organ. New results show that ...

Cancer-associated fibroblasts (CAF) expressing Lrrc15, encoding a conserved transmembrane protein, increased in prevalence as mouse pancreatic cancer tumors progressed, and an LRRC15+ TGFβ CAF ...

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