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转录因子 ONECUT3:结直肠癌治疗的新希望
ONECUT3 是与 CRC 糖酵解相关的关键转录因子 :研究人员分析 TCGA 数据库中结肠癌样本的 RNA 测序数据,根据糖酵解相关基因的表达水平将样本分为高糖酵解组和低糖酵解组,筛选出差异表达基因,发现 ONECUT3 是最显著的差异表达基因。通过免疫组化染色进一步证实,ONECUT3 在结直肠癌组织中的表达明显增加,暗示其可能通过糖酵解在 CRC 中发挥调控作用。
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