Voltage-gated sodium channels (VGSCs) are responsible for transmembrane (TM) sodium ion conduction and, in eukaryotes, for electrical signalling in excitable cells 1. In humans, mutations in different ...

Most natural proteins performing sophisticated tasks contain multiple domains where an active site is located at the domain interface. Comparative structural analyses suggest that major leaps in ...

Hsp70 chaperone systems are very versatile machines present in nearly all living organisms and in nearly all intracellular compartments. They function in many fundamental processes through their ...