In each, the monomers consist of a TM domain that contains the voltage sensor and pore functionalities, and a C-terminal domain (CTD) that may have a role in assembly of the tetrameric channels 5, 6.

Most natural proteins performing sophisticated tasks contain multiple domains where an active site is located at the domain interface. Comparative structural analyses suggest that major leaps in ...

Hsp70 chaperone systems are very versatile machines present in nearly all living organisms and in nearly all intracellular compartments. They function in many fundamental processes through their ...