“We could already quantify small sensory fibers using intra-epidermal ... The technique clearly differentiated patients with mild neuropathy from healthy controls, with diabetics showing lower ...

[4,5,6] Only a few patients had signs or symptoms of neuropathy. They were mainly in the form of distal sensory loss, parasthesias, absent ankle jerks and, in two patients, mild motor weakness.

in the remainder there was only a subjective sensory difference. In no case was the corneal reflex lost, and only one patient noted a mild difference between the two sides when this reflex was tested.

They were generally mild and not disabling. Seven (21%) patients had clinical signs of peripheral neuropathy. Sensory impairment was present in four (12%) patients and motor weakness in two ...