We and others have shown that σ2R/TMEM97 ligands alleviate mechanical hypersensitivity in mouse neuropathic pain models with a time course wherein maximal antinociceptive effect is approximately ...

Dietmar Thal, Prof. Bart De Strooper, and Dr. Sriram Balusu demonstrates they can indeed prevent loss of nerve cells in a mouse model of Alzheimer's using specific inhibitors. "Nerve cells die in ...