Tumor necrosis factor-mediated downregulation of spinal astrocytic connexin43 leads to increased glutamatergic neurotransmission and neuropathic pain in mice. Brain, Behavior, and Immunity , 2015 ...

A research group from Hiroshima University investigated the effects of altered spinal astrocytic Cx43 expression and pain-related behavior following peripheral nerve injury.

A research group from Hiroshima University demonstrated that the downregulation of spinal astrocyte connexin43 (Cx43) expression causes sustained neuropathic pain following peripheral nerve injury.

New molecular mechanism of neuropathic pain in mice. Hiroshima University. Funder Grant-in-Aid for Scientific Research of the Japan Society for the Promotion of Science ...

The downregulation of spinal astrocyte connexin43 (Cx43) expression causes sustained neuropathic pain following peripheral nerve injury. The inflammatory cytokinetumor necrosis factor (TNF) mediates ...

Animal models are critical in improving our understanding of neuropathic pain processes, enabling the discovery and development of new pain management medicines.

The current neuropathic pain study by Li and Tolias used mouse models of neuropathic pain caused by nerve injury, chemotherapy or diabetes. The researchers showed that Tiam1 is activated in the spinal ...

Neuropathic pain -- abnormal hypersensitivity to stimuli -- is associated with impaired quality of life and is often poorly managed. Estimates suggest that 3 percent to 17 percent of adults suffer ...

Certain personality traits such as sociability, anxiety or depression influence manifestations of neuropathic pain in mice, according to a new study by the Neuropharmacology Laboratory-NeuroPhar ...

Researchers have discovered a non-opioid compound that, in mice, effectively reduced the pain hypersensitivity associated with chronic and often debilitating nerve pain caused by diabetes or ...