This paper focuses on the problem of maximum likelihood estimation in linear mixed-effects models where outliers or unduly large observations are present in clustered or longitudinal data.

The mixed effects model for binary responses due to Conaway (1990, A Random Effects Model for Binary Data) is extended to accommodate ordinal responses in general and discrete time survival data with ...

Within the past few years, models that can predict the structure or function of proteins have been widely used for a variety of biological applications, such as identifying drug targets and designing ...