编辑推荐： 本研究针对HIV-1潜伏库量化难题，创新性地将完整前病毒DNA检测技术 (IPDA)适配至芯片数字PCR (dPCR)平台，采用CCR5替代传统RPP30作为参考基因，系统评估了其在HIV-1不同亚型中的检测效能。结果表明该技术显著减少操作时间，在ART治疗者中实现高特异性检测，为非B亚型样本的精准量化提供 ...

HiCapR uncovers HIV RNA homodimers and long-range interactions that show structural dynamics critical for viral packaging and assembly.

To address these limitations, we conducted single-cell multi-omics analyses on PBMCs from people living with HIV (PLWH) in the early stages of infection. Using a targeted sequencing strategy, we ...

After incorporating the DNA of HIV-1 into the genome of every tissue of the animals' bodies, the team found it could delete targeted fragments of HIV-1 from the genome in most tissues.

The success and pathogenicity of HIV-1 largely resides in the function of the viral protein Nef. Here, the authors propose that Nef modulates a T cell's ability to form an immunological synapse ...

However, a small percentage of HIV-1-positive individuals maintain good general conditions and show either delayed or even no signs of disease progression several years after infection, despite ...

Do HIV-1 Variants Contribute to Establishing an Extreme Phenotype of Infection? A number of studies have argued that gross mutations or deletions within the HIV accessory genes can lead to virus ...

ICVAX employs Immuno Cure's patented PD-1-Enhanced DNA Vaccine technology, which aims to achieve sustained, immune-mediated HIV-1 virological control without the need of ART.

The N-heptad repeat (NHR) of the HIV-1 gp41 prehairpin intermediate (PHI) is an attractive potential vaccine target with high sequence conservation across diverse strains. However, despite the potency ...

Immuno Cure BioTech, a clinical-stage biotechnology group based in Hong Kong Science Park, announced its upcoming collaboration with PharmaJet to evaluate the safety and immunogenicity of HIV ...

The Statistical Center for HIV/AIDS Research and Prevention (SCHARP), located at Fred Hutch Cancer Center, is a statistical and data management center (SDMC) dedicated to supporting investigators who ...