The objective of our study was to evaluate high-dose cytarabine in consolidation therapy in patients with newly diagnosed acute promyelocytic leukemia (APL). Patients (age 16–60 years) received ...

The high-dose therapy arm was nevertheless associated with an improved response rate (92 versus 59%, P=0.01) and improved disease-free survival at 1 year (46 versus 19%, P=0.0001).

Table 2. Pharmacokinetic Values PARAMETER THIAMINE DOSE; 100 mg 500 mg 1500 mg; AUC 0–10 hr (nmol/Liter × hours): whole blood: 214 ± 69: 623 ± 178: 2046 ± 1222: plasma: 177 ± 62 ...

The overall effect of treatment condition (thiamine dose) on AUC 0–10 hr in blood and plasma was tested using analysis of variance (ANOVA) for repeated measures.

However, high dose exercise therapy provided superior outcomes related to function in sports and recreation in the short term, with results subsiding after six months.

By Dr. Liji Thomas, MD Research uncovers a potential link between gut bacteria and chronic fatigue in IBD patients, with specific microbes predicting the success of thiamine therapy for fatigue ...

The primary treatment is high dose thiamine supplementation due to the thiamine transporter-2 deficiency in Leigh syndrome. Thiamine helps restore energy production, preventing muscle weakness ...

Researchers from Karolinska Institutet have compared high dose exercise therapy versus low dose in patients with symptomatic knee osteoarthritis. The study published in the journal Annals of ...

In one small preliminary study, high doses of thiamine reduced chronic fatigue, which may be mediated by alterations in the gut microbiota.The current study further assessed the role of the gut ...

An abundance of Faecalibacterium prausnitzii or Roseburia hominis may predict the effectiveness of high-dose thiamine treatment to alleviate chronic fatigue in quiescent inflammatory bowel disease ...

He was just 5.5 years of age when his DMD was diagnosed, and for 21 years he was treated with once-daily 1.1-mg deflazacort, a corticosteroid that acts as an anti-inflammatory and immunomodulatory ...