本研究揭示了宿主细胞因子HCF-1在肝脏代谢调控中的核心作用。研究人员通过构建肝细胞特异性HCF-1敲除小鼠模型，发现HCF-1缺失会导致O-GlcNAc转移酶（OGT）蛋白稳定性下降、核定位丧失及全局O-GlcNAc糖基化水平降低，这种效应与禁食状态下的代谢响应高度相似。

Microsoft today announced that it acquired Lumenisity, a U.K.-based startup developing “hollow core fiber (HCF)” technologies primarily for data centers and ISPs. Microsoft says that the purchase, the ...