Phase I and Pharmacologic Study of Oral ZD9331, A Novel Nonpolyglutamated Thymidylate Synthase Inhibitor, in Adult Patients With Solid Tumors ABSTRACT: Aberrant gene expression is critical for tumor ...

Researchers at the Jackson Laboratory (JAX), the Broad Institute of MIT and Harvard, and Yale University, have used artificial intelligence (AI) to design thousands of new DNA switches that can ...

Phase II study of neoadjuvant FLOT and chemoradiation for trimodality therapy of esophageal/GEJ adenocarcinoma. This is an ASCO Meeting Abstract from the 2025 ASCO Gastrointestinal Cancers Symposium.

Scientists at the MRC Laboratory of Medical Sciences (LMS) have discovered a DNA-based “dimmer switch” that regulates the activity of a critical developmental gene, Cdx2. This work could pave the way ...

A new international study suggests that ancient viral DNA embedded in our genome, which were long dismissed as genetic "junk", may actually play powerful roles in regulating gene expression. Focusing ...

A recent study marks the first reported instance of generative AI designing synthetic molecules that can successfully control gene expression in healthy mammalian cells. As a proof-of-concept, the ...

Professor Asaf Hellman and his research team at the Hebrew University-Hadassah Medical School have unveiled new findings in the realm of methylation-directed regulatory networks. Their study sheds ...

A study published today in the journal Cell marks the first reported instance of generative AI designing synthetic molecules that can successfully control gene expression in healthy mammalian cells.

Long non-coding RNAs (lncRNA) are a type of RNA molecule that do not carry instructions to make proteins. Instead, they influence how other genes are expressed. There are tens of thousands of lncRNAs ...

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