资讯

Medical News Today

What is DNA and how does it impact health?

DNA is a biological molecule that contains the instructions an organism needs to function, develop, and reproduce. It is present in all forms of life on earth and contains each organism’s genetic code ...
Nature

Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal ...

Figure 2: Frequency distribution of telomere fluorescence shows telomere shortening associated with the lack of PARP. Figure 3: Lack of PARP does not affect the presence of single strand overhangs at ...
eLife

Type I and type III interferon receptor knockout chickens: Novel models for unraveling ...

Department of Veterinary Sciences, Ludwig-Maximilians-Universität München, Munich, Germany ...
生物通

发光Ln(III)噻吩羧酸配合物的合成、DNA结合及细胞毒性研究：新型抗癌 ...

本文报道了四种新型异核噻吩羧酸镧系配合物[Ln2(tph)4(OAc)2(phen)2]（Ln=Gd/Eu/Sm/Tb）的合成与表征。通过X射线衍射证实其异羧酸桥 ...
腾讯网

PARP抑制剂在前列腺癌治疗中的作用

很多朋友不了解PARP抑制剂在前列腺癌中的应用，更不太清楚什么情况下使用更好，因此我从肿瘤特征以及PARP抑制剂的作用机制入手，将这个问题写明白，希望对广大患者朋友有帮助! 第1节：PARP抑制剂在癌症治疗中的分子基础 1.1 DNA损伤应答（DDR）网络：BER和HRR通路概述 ...
腾讯网

任捷团队Trends in Genetics综述丨新生RNA：转录与复制冲突的重要调控者

在细胞生命活动的核心，DNA既要被复制以传承遗传信息，又要被转录以指导蛋白质合成等功能。由于这两个分子事件共享同一条DNA模板，当它们同时进行、“狭路相逢”时，便会发生转录-复制冲突（Transcription replication conflicts, TRCs）。尽管细胞通过多种方式减少 ...