The Denver Broncos, led by quarterback Bo Nix, face the Indianapolis Colts, led by quarterback Daniel Jones, on Sunday, Sept. 14, 2025 in Week 2 of the NFL season at Lucas Oil Stadium in Indianapolis.

Coming off a dominant Week 1 victory, the Indianapolis Colts are again at home in Week 2, this time taking on the Denver Broncos. Denver is coming off a 20-12 win last weekend over the Tennessee Titans. Quarterback Bo Nix was 25-of-40 passing for 176 yards with a touchdown and two interceptions.

After earning a season-opening win in orange in Week 1, Denver will rep the same jersey color for a Week 2 road game against the Indianapolis Colts. "It's not about the stats or it's not about perfection by the outside, but it's just, for me, a standard that I have for myself, and I know that I can be better," Nix said Wednesday.

The Indianapolis Colts beat the Denver Broncos in NFL Week 2 action: Live score updates, stats, highlights, injuries.

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Update: Broncos lose to the refs, err, I mean they lost to the Colts. On the road in Week 2, the Denver Broncos will take on the Indianapolis Colts. Both teams started the season with a win last week and look to remain perfect on the season in this game.

T he Houston Texans play their home opener against the Tampa Bay Buccaneers at 6 p.m. today as part of a Monday Night Football doubleheader. The Texans' offense under new coordinator Nick Caley was still working out the kinks in an opening 14-9 loss to the Los Angeles Rams.