例如，对COL4A3/COL4A4/COL4A5基因致病变异的识别，可改变Alport综合征患者的监测策略。 研究还强调，动态更新机制可确保panel持续反映基因-疾病关联的新证据。

Hereditary nephritis is caused by mutations in genes responsible for the structural integrity and function of the glomerular basement membrane (GBM). In dogs, mutations in the COL4A3, COL4A4, and ...

肌成纤维细胞与壁层上皮细胞的病理性互作 CellChat分析显示：随着eGFR下降，MyoFib2通过COL4A4- (ITGAV+ITGB8)等配体-受体对增强与PEC的互作，同时招募免疫细胞加速纤维化进程。 TGF-β信号从内皮细胞转向肌成纤维细胞主导。

Cardiac fibroblasts play a critical role throughout the various phases of murine heart development ranging from the embryonic to the neonatal stage.

This group of genes includes Col4a4, Col4a5, Col4a6, and Ntn4. Finally, we identified the fifth group of genes displayed universal expression in all four chambers at most stages. This gene group ...