例如，对COL4A3/COL4A4/COL4A5基因致病变异的识别，可改变Alport综合征患者的监测策略。 研究还强调，动态更新机制可确保panel持续反映基因-疾病关联的新证据。

Hereditary nephritis is caused by mutations in genes responsible for the structural integrity and function of the glomerular basement membrane (GBM). In dogs, mutations in the COL4A3, COL4A4, and ...