All of the updated Week 1 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 1 NFL picks now.

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Fantasy football 2025 rankings, draft prep: Model unveils QB, RB, WR, TE picks, NFL cheat sheets, ADP, tiers SportsLine simulated the new NFL season 10,000 times and revealed its 2025 Fantasy ...