Fragile X disorders include two distinct conditions: fragile X syndrome (the most common single-gene cause of developmental delay and autism) and an entirely separate group of premutation syndromes.

Intravenous thrombolysis remains a standard treatment for acute ischemic stroke within 4.5 hours after onset. Vascular reocclusion may occur after intravenous thrombolysis and may be preventable ...

The author describes the scientific foundations and implications of a study on variant EPO and erythrocytosis.

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A 64-year-old man presented with a 5-month history of a painful ulcer of the lateral left ankle. Recently, he had noticed malodorous secretions, increased erythema and edema, and worsening pain.

Explore the current issue of The New England Journal of Medicine (Vol. 393 No. 2).

After decades of undergoing epidemiologic study, prostate cancer remains an enigmatic disease; the only established risk factors are older age, family history of prostate cancer, and African ancest ...

A 19-year-old beach lifeguard from southern California presented with two asymptomatic, erythematous, raised, serpiginous eruptions on the posterior and right lateral surfaces of the neck.

NEJM uses highly rigorous editorial, peer, and statistical review processes to evaluate manuscripts for scientific accuracy, novelty, and importance.

There are gaps in uptake of, adherence to, and persistence in the use of preexposure prophylaxis for human immunodeficiency virus (HIV) prevention among cisgender women. We conducted a phase 3, dou ...

Only about 25% of U.S. women exclusively breast-feed for their infants’ first 6 months. After her own struggles, these statistics seem realistic to a physician-mother, who previously had no ...