COPD is a progressive disease where airway inflammation plays an important part. Previously, there were large expectations that regular anti-inflammatory treatment with inhaled corticosteroids (ICS) ...

Background Infections with some bacteria, including Streptococcus pneumoniae , have been associated with a reduced incidence of asthma. Components of S pneumoniae may have the potential to modulate ...

Background Antimicrobial resistance (AMR) is a growing global health crisis and is particularly relevant to people living ...

Asthma exacerbations are common. They account for a significant morbidity and contribute a disproportionate amount to the cost of asthma management. The optimal strategies for the prevention of asthma ...

Background Mutations in BMP type II receptor (BMPR-II) account for 70% of heritable pulmonary arterial hypertension (PAH) cases, but low penetrance (~20%) in mutation carriers implies a ‘second hit’ ...

Background There is a lack of international consensus on the optimal programme design to maximise benefits from pulmonary rehabilitation (PR). Aim To investigate the effect of 1) exercise modality and ...

Background: Considerable research has been conducted into the nature of airway inflammation in chronic obstructive pulmonary disease (COPD) but the relationship between proximal airways inflammation ...

To determine whether asthma alone can cause irreversible airflow obstruction 42 men and 47 women with chronic asthma (mean duration 22 (SD 13) years) without evidence of other disease likely to cause ...

Background Up to 50% of patients suffering acute pulmonary embolism (PE) demonstrate impaired pulmonary vascular recovery at follow up despite optimal anticoagulation, impacting negatively on ...

Methods Pre-clinical work captured clinically relevant extremes of respiratory parameters using a pediatric mannequin and mechanical ventilation. Biosensor data was compared to ventilator-measured ...

Results 256 day case MTs were analysed. Mean age was 72 years (34–86), 93 patients were male. 64 patients (25%) developed post procedure SE, and 4 of those had concurrent air leaks (due to lung ...

Despite the debilitating and lethal nature of pulmonary hypertension (PH) secondary to interstitial lung disease (group 3 PH),1 research into the treatment of this unique category of vasculopathy ...