Obviously, a key fourth-quarter fumble dampened Henry's night, which otherwise was easily the best Week 1 of his NFL career. Henry's previous high in Week 1 was 116 yards back in 2020. He only ran for that much twice last year, and one was 199 – also against Buffalo.

Now, the model has scoured the Week 3 NFL odds and locked in five confident NFL best bets. If you successfully parlay its picks, you'd be looking at a massive payout of around 25-1. You can only see the model's Week 3 NFL picks at SportsLine ,

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Should I start Bhayshul Tuten, Javonte Williams, Tony Pollard for Week 3? Fantasy football start 'em, sit 'em picks and recommendations for the 2025 NFL season.

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The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a 33-17 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Both the Cardinals and 49ers are playing with "house money" at 2-0, but only one team can push its win streak to three after their matchup on Sunday.

In Nate Davis' new NFL power rankings for Week 3, the Cardinals still are in the top half in the league, although they did drop a little bit. The Cardinals fell from No. 11 to No. 13 this week. They got big plays from Josh Sweat and Calais Campbell defensively.