Diabetic nephropathy is the leading cause of kidney disease in patients starting renal replacement therapy and affects ~40% of type 1 and type 2 diabetic patients. It increases the risk of death ...

Table 1. Diabetic Nephropathy Stages: Cutoff Values of Urine Albumin for Diagnosis and Main Clinical Characteristics Stages Albuminuria cutoff values (ref. 14) Clinical characteristics (ref. no.) ...

ASCEND was a multicenter, placebo-controlled trial that aimed to investigate the effects of the endothelin-A (ET A) receptor antagonist avosentan in patients with diabetic nephropathy.The study ...

The alternative complement pathway plays a key role in the pathogenesis of IgA nephropathy. Iptacopan specifically binds to factor B and inhibits the alternative pathway. In this phase 3 ...

"These data further our understanding of the role of CD38 + antibody secreting cells in IgA nephropathy pathogenesis," said corresponding author Millie Shah, Ph.D., Senior Scientist at Biogen.