Some of the same compounds used as RTIs can also block HBV replication; when used in this way they are referred to as polymerase inhibitors. [citation needed] While NRTIs and ... This, combined with ...
Generally, the dual NRTI backbone treatment of combination with a non-NRTI (NNRTI) or protease inhibitor (PI) should comprise a cytidine analogue (lamivudine, emtricitabine) and a thymidine ...
HIV-1 RT does not have proof-reading activity. This, combined with selective pressure from the drug, leads to mutations in reverse transcriptase that make the virus less susceptible to NRTIs and ...
The combination of these drugs with nucleoside reverse transcriptase inhibitors began the era of highly active antiretroviral therapy (HAART), transforming HIV infection from a death sentence to a ...