We and others have shown that σ2R/TMEM97 ligands alleviate mechanical hypersensitivity in mouse neuropathic pain models with a time course wherein maximal antinociceptive effect is approximately ...

Contineum Therapeutics, Inc. (NASDAQ: CTNM) (Contineum or the Company), a clinical stage biopharmaceutical company focused on discovering and developi ...

In a rat model of neuropathic pain, mild cooling of the skin or peripheral or central application of icilin produced marked analgesic effects, inhibiting sensitization of dorsal-horn neurons and ...

More information: Mikael Åkerlund et al, Genetic associations of neuropathic pain and sensory profile in a deeply phenotyped neuropathy cohort, Pain (2024). DOI: 10.1097/j.pain.0000000000003463 ...

"Using our atlas, we identified different pain-related phenotypic states of nociceptors (pain-sensitive nerve cells) that are ...

Study Overview and Results The study used the paclitaxel (PTX) model, where neuropathic pain was induced in mice through the administration of PTX, a common chemotherapy drug. While effective in ...

The latest preclinical study, conducted using a nerve ligation-induced neuropathy model in female rats, demonstrated that low doses of oral Ketamir-2 provided significant pain relief by Day 15.

Neuropathic pain drugs found to increase risk of hip fracture in older adults Date: November 13, 2024 Source: Monash University Summary: A new study by medicine safety experts found the use of ...