Houston has one giveaway and CJ Stroud is the more trustworthy quarterback at 3-1 against Jacksonville in his young career. Over the last 14 meetings, Houston has won 12 versus Jacksonville. I grabbed the Texans at +1.5 for -112 odds and would go down to the ML as they could close as the favorite.

The Indianapolis Colts try to remain undefeated while keeping the Tennessee Titans winless. Here are the Titans' key players entering Week 3.

According to the SportsLine Inside the Lines team and Projection Model, no NFL team's season swings more on its Week 3 outcome than the Steelers'

Mike Florio and Chris Simms preview a Week 3 duel between the Steelers and Patriots at Gillette Stadium, detailing why "Pittsburgh's defense is going to start playing better football" against an iffy New England offense.

Pregame analysis and predictions of the Indianapolis Colts vs. Tennessee Titans NFL game to be played on September 21, 2025 on ESPN.