the mouse has become the model of choice. Here the authors re-examine the value of this mouse model as a tool for understanding human diabetes and for testing potential therapies, reviewing both ...

Immunity plays a central role in the fight against cancer. Many of the current immunotherapies aim at helping the patient's ...

Selecting an appropriate mouse model is one of the most important decisions a pre-clinical researcher can make. Which is best suited for immuno-oncology? Cancer research and drug discovery has ...

Every year, over 1.5 million new cases of prostate cancer are diagnosed throughout the world. As one of the leading causes of ...

They created a mouse model that recapitulates the early non-motor symptoms as well as the motor difficulties in Parkinson's disease in a manner that directly mimics the condition in many patients.

Scientists from the Cardiovascular Research Center at the University of Virginia School of Medicine and Astrazeneca plc have developed a new mouse model of cardiovascular disease associated with ...

Our objective was to create a mouse model to determine if PNLIP p.T221M causes CP and to define the mechanism. Design We created a mouse model of Pnlip p.T221M and characterised the structural and ...

Objectives To characterise blood biochemistry and arthropathy in the AKU mouse model (Hgd−/−). To examine the therapeutic effect of long-term treatment with nitisinone, a potent inhibitor of the ...