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Some of those ingredients are, frustratingly, wildly popular ones — prescription retinoids, over-the-counter retinols, hydroquinone, benzoyl peroxide, and salicylic acid, to name a few.

What are the best League of Legends champions right now? Metas change, the LoL tier list will fluctuate, and it could be that your favorite champion might not be in a great place right now.