Thus high doses of thiamine hydrochloride may be absorbable. There is very limited pharmacokinetic data of oral thiamine at doses that are typically used and virtually no data on high-dose oral ...

Table 2. Pharmacokinetic Values PARAMETER THIAMINE DOSE; 100 mg 500 mg 1500 mg; AUC 0–10 hr (nmol/Liter × hours): whole blood: 214 ± 69: 623 ± 178: 2046 ± 1222: plasma: 177 ± 62 ...

They studied control and diabetic rats for 24 weeks with and without oral high-dose therapy with thiamine. "We found that thiamine therapy (70 mg/kg) prevented diabetes-induced increases in plasma ...

The high-dose therapy arm was nevertheless associated with an improved response rate (92 versus 59%, P=0.01) and improved disease-free survival at 1 year (46 versus 19%, P=0.0001).

The objective of our study was to evaluate high-dose cytarabine in consolidation therapy in patients with newly diagnosed acute promyelocytic leukemia (APL). Patients (age 16–60 years) received ...

However, high dose exercise therapy provided superior outcomes related to function in sports and recreation in the short term, with results subsiding after six months.

The primary treatment is high dose thiamine supplementation due to the thiamine transporter-2 deficiency in Leigh syndrome. Thiamine helps restore energy production, preventing muscle weakness ...

Targeted, high-dose stereotactic body radiation therapy appears to benefit some patients with pancreatic cancer. ScienceDaily . Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2015 ...

Researchers from Karolinska Institutet have compared high dose exercise therapy versus low dose in patients with symptomatic knee osteoarthritis. The study published in the journal Annals of ...