本研究揭示了宿主细胞因子HCF-1在肝脏代谢调控中的核心作用。研究人员通过构建肝细胞特异性HCF-1敲除小鼠模型，发现HCF-1缺失会导致O-GlcNAc转移酶（OGT）蛋白稳定性下降、核定位丧失及全局O-GlcNAc糖基化水平降低，这种效应与禁食状态下的代谢响应高度相似。

Have you ever found yourself wrestling with Excel formulas, wishing for a more powerful tool to handle your data? Or maybe you’ve heard the buzz about Python in Excel and wondered if it’s truly the ...

HCF has announced a planned leadership transition, with CEO Sheena Jack (pictured) set to retire on July 1. Jack’s departure will mark the end of a 15-year tenure in executive roles at HCF, including ...

Abstract: Distracted driving causes a large number of traffic accident fatalities and is becoming an increasingly important issue in recent research on traffic safety. Gesture patterns are less ...

Sophie Venz is a former Deputy Editor at Forbes Advisor. She is an experienced editor and features reporter, and has previously worked in the small business and start-up reporting space. Previously ...

Python is powerful, versatile, and programmer-friendly, but it isn’t the fastest programming language around. Some of Python’s speed limitations are due to its default implementation, CPython, being ...

The Hawaiʻi Community Foundation (HCF) today launched the Stronger Hawaiʻi initiative to provide information and resources to Hawaiʻi communities when faced with disasters. Designed to support the ...

HCF honors nonprofit leaders with 2024 Ho‘okele Awards. Recipients include: (R to L) Janice Ikeda, Founding Executive Director, Vibrant Hawai‘i; Kelly Maluo-Pearson, CEO, Boys & Girls Club of Maui; ...

You can create a release to package software, along with release notes and links to binary files, for other people to use. Learn more about releases in our docs.