InFlectis BioScience, a clinical-stage biotechnology company focused on developing therapies for neurodegenerative diseases, is proud to announce the acceptance of its latest research article titled ...

Over time, the neighborhood falls into disrepair. A critical protein that MSNs need to stay alive, called DARPP-32, starts to ...

A natural way to address depression, anxiety, and chronic pain is diet: We need to avoid eating ultra-processed foods that ...

Glutamate excitotoxicity mediated by the AMPA/kainate type of glutamate receptors damages not only neurons but also the myelin-producing cell of the central nervous system, the oligodendrocyte 1.

Glutamate excitotoxicity is a common neuropathology found in many neurodegenerative disorders. The excessive release of glutamate, an excitatory neurotransmitter, due to trauma or disease often lead ...

On the other hand, glutamate (Glu)-induced excitotoxicity during brain ischemia leads to an intracellular cascade of cytotoxic events [36]. It has been described in an astrocytic cell line that UTP ...

This indicates that a transient metabolic failure can persistently alter glutamatergic synaptic transmission. Whether this also applies to glutamate release and glutamate uptake is currently not known ...

Glutamate-induced excitotoxicity has been implicated as a causative factor for selective neuronal loss in ischemia and hypoxia. Toxic exposure of neurons to glutamate results in an extended neuronal ...

Excitotoxicity is the pathological process by which neurons are damaged and killed by the overactivations of receptors for the excitatory neurotransmitter glutamate, such as the NMDA receptor and ...

We searched medical databases to find all relevant studies (specifically randomised controlled trials) completed up to 30 July 2020. To be included in the review, studies had to compare ketamine or ...