Glutamate excitotoxicity mediated by the AMPA/kainate type of glutamate receptors damages not only neurons but also the myelin-producing cell of the central nervous system, the oligodendrocyte1.

In recent years, glutamate ‘excitotoxicity’ has been proposed as a mechanism by which retinal ganglion cells die in glaucoma. 1 If true, this could lead to exciting new treatments for glaucoma.

Excitotoxicity is the pathological process by which neurons are damaged and killed by the overactivations of receptors for the excitatory neurotransmitter glutamate, such as the NMDA receptor and ...

These prevented excitotoxicity (right). [Courtesy of Yan et al., 2020 Science/AAAS.] Yan found that TwinF bound to a stretch of 18 amino acids on the cytosolic side of GluN2A and GluN2B, close to the ...

Huizhen Sun, Shanshan Wei, Yanchun Gong, Kaizhi Ding, Shan Tang, Wei Sun, Chunhua Yuan, Liping Huang, Zhibing Liu, Chong Chen, Lihua Yao, Neuroprotective effects of cordycepin inhibit ...

Glutamate excitotoxicity is thought to be a factor in neurodegenerative diseases such as amyotrophic lateral sclerosis (see ARF related news story on Aizawa et al., 2010 and Cucchiaroni et al., 2010) ...

[Purdue University image/Tran Nguyen] “Glutamate excitotoxicity is a pathology in which excessive glutamate can cause neuronal damage and degeneration.

This is known as excitotoxicity. Researchers have been studying therapies that attempt to inhibit glutamate activity for the treatment of ALS , as noted by the ALS Association .