Gentamicin dosing is highly variable and remains complicated in the neonatal population. Traditional dosing in our unit resulted in an excessive number of elevated trough serum gentamicin levels. We ...

Appropriate dosage determination for aminoglycosides helps to achieve desirable levels of drug in the blood, thereby reducing the probability of ototoxicity, nephrotoxicity, and treatment failure. The ...

It is widely documented that aminoglycosides, including gentamicin, are nephrotoxic to the proximal renal tubules, with an incidence ranging widely from 2% to 50%, depending on the source.