The Mre11 complex (Mre11, Rad50 and Xrs2 in Saccharomyces cerevisiae) influences diverse functions in the DNA damage response. The complex comprises the globular DNA-binding domain and the Rad50 hook ...

This is a preview. Log in through your library . Abstract The problem of minimizing a concave function subject to linear inequality constraints may have many local solutions. Therefore, finding the ...