STAT3 then turns on the protein Integrin β3 (ITGB3) in mouse and human cells, which fuels the growth of pancreatic ductal adenocarcinoma (PDAC), the most common form of pancreatic cancer.

In a study published in Nature, University of Michigan researchers have identified that the balance between two proteins – STAT3 and STAT5 – is important for making tumors vulnerable to immune ...

Figure 1: (A) Canonical STAT3 activation pathway. (B) WP1066 and TTI-101, examples of small molecule STAT3 inhibitors that are cell penetrant. Pediatric H3K27M-mutant diffuse midline gliomas (DMGs ...

Activation of STAT3 in cancers leads to gene expression promoting cell proliferation and resistance to apoptosis, as well as tumor angiogenesis, invasion, and migration. In the characterization of ...