Although technologies have advanced significantly since the first approval was given for a clinical trial of a gene therapy product in 1990, many challenges remain. 1 Among them is the need for fast, ...

Cis-elements within retroviral expression constructs increase vector titer and/or gene transfer efficiency. Several approaches for expressing multiple genes in a single vector are available. The ...

The distribution of the latent vectors of a sample covariance matrix was found by T. W. Anderson [1] (1951) when the population covariance matrix is a scalar matrix, Σ = σ2I. The asymptotic ...

Compositional data, consisting of vectors of proportions, have proved difficult to handle statistically because of the awkward constraint that the components of each vector must sum to unity. Moreover ...