It is reported that up to 10–25% of all diagnoses of inflammatory bowel disease (IBD) occur in those aged less than 18 years.1 The long-term impact of disease for those likely to live 70+ years with ...

Background Gut microbial metabolites are recognised as critical effector molecules that influence the development of colorectal cancer (CRC). Peptidoglycan fragments (PGFs) produced by microbiota play ...

Correspondence to Dr Melina Arnold, Section of Cancer Surveillance, International Agency for Research on Cancer, 150 Cours Albert Thomas, Lyon 69008, France; arnoldm{at}fellows.iarc.fr Objective The ...

Background: Identification of patients at risk for mortality early in the course of acute pancreatitis (AP) is an important step in improving outcome. Methods: Using Classification and Regression Tree ...

Background Despite the long-standing recommendations of high-protein diets for patients with cancer, the precise mechanisms of this dietary approach in benefiting tumour suppression and enhancing ...

2 Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan 3 Department of Internal Medicine, GI Unit, Massachusetts General Hospital, Boston, Massachusetts, USA 4 ...

Upper gastrointestinal bleeding (UGIB), especially peptic ulcer bleeding, remains one of the most important cause of hospitalisation and mortality world wide. In Asia, with a high prevalence of ...

We have recently reported the immune-promoting effects of butyrate in microsatellite stable (MSS) colorectal cancer (CRC) based on mouse models.1 However, its potential application in human CRC and ...

1 Department of Gastroenterology and Hepatology, Erasmus MC Rotterdam, Rotterdam, The Netherlands 2 Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The ...

2 School of Psychology, University of Southampton, Highfield, Southampton, UK Correspondence to: Dr R Moss-Morris School of Psychology, University of Southampton, Highfield, Southampton SO17 1BJ, UK; ...

Objective In the tumour microenvironment, critical drivers of immune escape include the oncogenic activity of the tumour cell-intrinsic osteopontin (OPN), the expression of programmed death ligand 1 ...

Background Covid-19 Induced Hepatitis (CIH), is a novel terminology which is used in this article for the first time in the medical literature. Objective To study the pattern of liver impairment in ...