A new study shows that lowering MSH3, a key DNA repair protein, with antisense oligonucleotide (ASO) therapy can stop CAG ...

The good news? You don’t need to be a scientist to protect yourself from hype and heartbreak. So, HDBuzz has Ten Golden Rules ...

Ed is a neurologist at the National Hospital for Neurology and Neurosurgery, London, UK, and a Professor of Neurology at University College London where he is Associate Director of the Huntington’s ...

Roche gave an update this week about GENERATION HD2, testing the HTT-lowering drug tominersen in people with HD. The trial is ...

A recent paper links CAG repeat expansion with widespread RNA changes, especially in brain cells vulnerable to HD. “Knocking ...

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Jeff is an Associate Professor in the Department of Neurology at the University of Washington, Seattle, USA. Throughout his academic career, Jeff’s focus has been on better understanding, and ...

We often think of the adult brain like a completed jigsaw puzzle—once all the pieces are in place, that’s it. If a few pieces go missing, as happens in neurodegenerative diseases like Huntington’s ...