If Microsoft Access is not responding on your Windows computer, run it in Safe Mode, identify the offender and disable the add-in, to begin with.

Microsoft Office Access Can't Change the Working Directory. After transferring an existing workstation configuration to a new computer, a "Microsoft Access can't change the working directory ...

Microsoft Access is not available for Mac users, but here is how it can be installed on a Mac using a virtual machine. Its easy if you know how!