Major Finding: Transferrin receptor targeting chimeras (TransTAC) can degrade many membrane proteins of interest. Concept: Coupling membrane proteins to transferrin receptor 1 enables efficient ...

Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan. *Corresponding Author: Max S. Wicha, Department of Internal Medicine, University of Michigan–Ann Arbor, 2800 Plymouth Road ...

Copyright held by the owner/author(s). This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International ...

The Nobel Prize in Physics was awarded to John Hopfield, PhD, and Geoffrey Hinton, PhD, for their pioneering work in artificial neural networks, which laid the foundation for modern AI applications in ...

mRNA vaccines for COVID-19 were associated with higher PD-L1 expression in tumors and improved overall survival in patients with non–small cell lung cancer and metastatic melanoma who also received ...

Three scientists will share the Nobel Prize in Chemistry for creating computational tools that transformed protein structure prediction and design, accelerating cancer research and drug discovery.

The 2024 Nobel Prize in Medicine or Physiology recognized the discovery of microRNAs, small noncoding RNAs vital to regulating tumor biology. While early enthusiasm for microRNA-based therapies has ...

GSK agreed to pay $2.2 billion to settle approximately 80,000 lawsuits in U.S. courts over claims its heartburn drug, Zantac, caused cancer. The settlements account for 93% of all cases and were ...

Seven out of the 67 children who received a gene therapy for a devastating neurologic disorder developed blood cancer (N Engl J Med 2024 Oct 9 [Epub ahead of print]). The therapy, elivaldogene ...

High levels of the carcinogen benzene were found in more than a third of benzoyl peroxide–based acne products tested in a recent study (J Invest Dermatol 2024 Oct 7 [Epub ahead of print]). Benzoyl ...

Department of Medicine III – Hematology/Oncology, LMU University Hospital, LMU Munich, Munich, Germany.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York. *Corresponding Author: Marc Ladanyi, Department of Pathology and Laboratory Medicine, Memorial ...