Abstract. A formal National Cancer Institute Clinical Trials Cooperative Group Program was conceived in 1955 when Dr. Sidney Farber, Mary Lasker, and others approached Congress with a proposal to ...

Abstract. Objective: Hippo signaling pathway is known to regulate organ development. In Hippo signaling pathway, YAP or TAZ works as a transcriptional co-activator and forms a transcriptional complex ...

AbstractPurpose:. Antibody–drug conjugates (ADC) are a promising approach for the management of patients with non–small cell lung cancer (NSCLC). However, only a small subset of patients derive ...

Cancer cells are usually exposed to a multitude of stressors known to trigger senescence, including oncogenic signaling, replicative stress, hypoxia, reactive oxygen species, nutrient deprivation, and ...

Abstract. Background: ASC63 is an oral small molecule programmed cell death-ligand 1 (PD-L1) inhibitor. After oral dosing, ASC63 is rapidly absorbed and converted to its pharmacologically active ...

Abstract. Introduction: Increasing evidence suggest that epigenetic regulators play a critical role in cancer cell heterogeneity and in maintaining tumor sub-populations with enhanced tumor-initiating ...

Abstract. Interleukin-2 (IL-2) offers therapeutic potential for cancer treatment, however, its clinical application is limited due to systemic adverse effects, such as vascular leakage syndrome (VLS).

Fibroblast activation protein (FAP) is a promising target for diagnosing and treating numerous malignant tumors. 177 Lu-EB-FAPI (LNC1004) is a FAP-targeted radiopharmaceutical conjugated to Evans blue ...

Abstract. On March 23, 2022, the FDA approved Pluvicto (lutetium Lu 177 vipivotide tetraxetan, also known as 177Lu-PSMA-617) for the treatment of adult patients with prostate-specific membrane antigen ...

In a recent analysis based on the 2008 world wide estimates of cancer compiled by the International Agency for Research on Cancer (IARC, Lyon, France; Globocan 2008; ref. 1), it was estimated that 529 ...

Abstract. Deficiencies in oxygenation are widespread in solid tumors. The transcription factor hypoxia-inducible factor (HIF)-1α is an important mediator of the hypoxic response of tumor cells and ...

Perineural invasion is a common feature of pancreatic ductal adenocarcinoma (PDAC). Here, we investigated the effect of perineural invasion on the microenvironment and how this affects PDAC ...