Reports indicate that Juszczyk, who is 34 years old, cleared concussion protocol, according to Matt Barrows of The Athletic. Running back Christian McCaffrey and the 49ers can expect their star fullback to return to action on Sunday. Cornerback Siran Neal will also be available against the Cardinals.

The Arizona Cardinals have a chance at a 3-0 start when they head to San Francisco to take on the 49ers. It's their toughest matchup yet this year.

The San Francisco 49ers have been leaning on Christian McCaffrey early in the season. The star running back has 17.5 rushes per game through two weeks and has added 8.5 targets per game. His total of 26 looks per game has resulted in him leading the team in rushing and being second in receiving on the 49ers.

Who would have imagined that the San Francisco 49ers would start the season with a perfect 2-0 record, securing impressive wins against the New Orleans Saints (26-21) and the Seatt

The Arizona Cardinals' latest injury update, featuring Will Johnson and Paris Johnson Jr., is a mixed bag for the San Francisco 49ers game.

Which team will win the NFL Week 3 game? Check out these NFL Week 3 picks and NFL Week 3 predictions for the game, which can be seen at 1:25 p.m. MST on FOX (stream with FUBO).Start the day smarter.

The San Francisco 49ers opened practice Wednesday for Sunday’s game against the Arizona Cardinals with 10 players (six starters) on the injury report, eight of whom did not practice. Quarterback Brock Purdy, who missed Sunday’s game against the Saints, was limited.

After their Super Bowl run, the 49ers were forced to replace Greenlaw, who tore his Achilles against the Kansas City Chiefs. Rather than elevating Winters, San Francisco turned to longtime Falcon De’Vondre Campbell. Despite posting solid numbers, Campbell was abruptly released by the end of week 14.

Quarterback Brock Purdy is highly unlikely to start for the San Francisco 49ers on Sunday because of a toe injury

They aren't signs anymore. San Francisco 49ers fans will be disappointed by Brock Purdy's status for Week 3 against the Arizona Cardinals. Kyle Shanahan announc