Predictions, picks and odds for NFL Week 3 game

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Week 3 NFL odds, lines, betting picks, spreads: 2025 predictions: Model backs Packers and Colts
The Week 3 NFL schedule has an interesting blend of divisional rivalries and cross-conference showdowns. The former has Broncos vs. Chargers, with L.A. 2.5-point home favorites in the Week 3 NFL odds,

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SportsLine · 6h
NFL Week 3 odds, score predictions: SportsLine computer simulation model reveals picks for every game on the football schedule
NFL Week 3 predictions: ESPN matchup predictor's picks, win probabilities for this week
Baker Mayfield has thrived under pressure, leading the Buccaneers to another 2-0 start
The Tampa Bay Buccaneers are 2-0 for the fifth straight season thanks to Mayfield’s final-minute heroics two weeks in a row.

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Steelers LB Alex Highsmith out, DT Derrick Harmon might debut
Steelers likely to change returners after special teams gaffe
Tampa Bay Buccaneers beat Houston Texans in final seconds of Monday night thriller as Los Angeles Chargers move 2-0
Baker Mayfield led an 11-play, 80-yard drive capped by Rachaad White's two-yard touchdown run with six seconds left as the Tampa Bay Buccaneers beat Houston Texans 20-19 in a thrilling finish.

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Week 3 NFL Power Rankings: Overreactions, a new No. 1 and Vikings, Commanders drop
Vikings vs. Falcons takeaways: Atlanta’s defense, kicker shine against sputtering Minnesota

Daniel Jones' start impresses Colts captain Zaire Franklin: 'It ain't ever over for a quarterback'

Daniel Jones has excelled in his first two weeks as Indianapolis Colts quarterback. Here's what linebacker Zaire Franklin says about Jones.

Indianapolis Colts vs Denver Broncos results, scores, highlights, today: Colts win on field goal with no time left

The Indianapolis Colts beat the Denver Broncos in NFL Week 2 action: Live score updates, stats, highlights, injuries.

Cam Bynum and Colts mascot, Blue, gave us the best celebration of NFL Week 2

When the 2025 NFL schedule was released, you might not have penciled in the Week 2 matchup between the Denver Broncos and the Indianapolis Colts as the most entertaining of the week. After all, that game is lined up against the Super Bowl LIX rematch between the Philadelphia Eagles and the Kansas City Chiefs.
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