Retinoic acid, a vitamin A derivative, has long been used as a treatment in certain cases of neuroblastoma — but its effects vary depending on the disease context. While the drug has minimal impact on ...

Why retinoic acid is effective in this setting but not against primary tumors, has been speculated about for nearly 50 years. Scientists resolved the mystery, showing the drug 'hijacks' a normal ...

Neuroblastoma is a solid tumor that occurs in children. When high-risk, the disease has a poor prognosis. Decades ago, adding the drug retinoic acid to neuroblastoma treatment increased survival by 10 ...

Retinoic acid (RA) signalling is a fundamental biochemical pathway derived from vitamin A metabolism that orchestrates gene expression through its interaction with nuclear receptors. This signalling ...

Researchers demonstrate how the co-exposure of bisphenol A and retinoic acid (RA) potentiate the effect of RA signaling in early development. Synthetic chemicals and plastics are useful and ...

(L to R) Co-first and co-corresponding author Min Pan, PhD, co-first author Yinwen Zhang, PhD, St. Jude Department of Computational Biology, co-corresponding author John Easton, PhD, St. Jude ...