The basis for the prevention of diabetic nephropathy is the treatment of its known risk factors: hypertension, hyperglycemia, smoking, and dyslipidemia. These are also risk factors for ...

Taken together, it appears multiple pathways contribute to the initiation and progression of diabetic nephropathy beyond ... metabolism and the pathogenesis of T2D is still poorly understood.

Role of APRIL in IgA nephropathy pathophysiology One area of research in IgA nephropathy is APRIL (A Proliferation-Inducing Ligand), which plays a key role in the disease’s progression.

"These data further our understanding of the role of CD38 + antibody secreting cells in IgA nephropathy pathogenesis," said corresponding author Millie Shah, Ph.D., Senior Scientist at Biogen.

The alternative complement pathway plays a key role in the pathogenesis of IgA nephropathy. Iptacopan specifically binds to factor B and inhibits the alternative pathway. In this phase 3 ...