The impact of mutators on cancer therapy The expression of a mutator phenotype in human cancers and in particular the accumulation of subclonal and random mutations has important implications.

Moreover, the breakpoint junctions of GCRs from these GCR mutator mutants were determined with modified breakpoint-mapping methods. We also identified nine genes (AKR1, BFR1, HTZ1, IES6, NPL6, RPL13B, ...