Maximum likelihood algorithms are described for generalized linear mixed models. I show how to construct a Monte Carlo version of the EM algorithm, propose a Monte Carlo Newton-Raphson algorithm, and ...

Linear mixed models (LMMs) provide a powerful method for studying genotype–phenotype associations. Here the authors present a LMM application that estimates an optimal transformation from ...

For a univariate linear model, the Box-Cox method helps to choose a response transformation to ensure the validity of a Gaussian distribution and related assumptions. The desire to extend the method ...

This section introduces the mathematical notation used throughout this chapter to describe the mixed linear model. You should be familiar with basic matrix algebra (refer to Searle 1982). A more ...