Fluoride can come from a number of sources, including most toothpaste brands ... In extremely rare cases, high levels of fluoride exposure over long periods can lead to skeletal fluorosis ...

Fluoride in toothpaste has largely prevented the need ... it does not address the underlying issues such as high sugar ...

The widespread use of toothpaste and mouthwashes with added fluoride in recent decades appears to have diminished the known public health benefits of water fluoridation, a new study suggests.