The high-dose therapy arm was nevertheless associated with an improved response rate (92 versus 59%, P=0.01) and improved disease-free survival at 1 year (46 versus 19%, P=0.0001).

A prospective randomized trial was conducted to study the timing of high-dose intravenous melphalan and autologous stem cell transplantation (HDM/SCT) in AL amyloidosis. In all, 100 newly ...

Table 2. Pharmacokinetic Values PARAMETER THIAMINE DOSE; 100 mg 500 mg 1500 mg; AUC 0–10 hr (nmol/Liter × hours): whole blood: 214 ± 69: 623 ± 178: 2046 ± 1222: plasma: 177 ± 62 ...

Thus high doses of thiamine hydrochloride may be absorbable. There is very limited pharmacokinetic data of oral thiamine at doses that are typically used and virtually no data on high-dose oral ...

The primary treatment is high dose thiamine supplementation due to the thiamine transporter-2 deficiency in Leigh syndrome. Thiamine helps restore energy production, preventing muscle weakness ...

An abundance of Faecalibacterium prausnitzii or Roseburia hominis may predict the effectiveness of high-dose thiamine treatment to alleviate chronic fatigue in quiescent inflammatory bowel disease ...

In one small preliminary study, high doses of thiamine reduced chronic fatigue, which may be mediated by alterations in the gut microbiota.The current study further assessed the role of the gut ...

By Dr. Liji Thomas, MD Research uncovers a potential link between gut bacteria and chronic fatigue in IBD patients, with specific microbes predicting the success of thiamine therapy for fatigue ...